Atlético de Madrid will be in the next round of the Copa de la Reina after winning the red and white clash. Andrea Medina sent the first warning with a header, but it was Synne Jensen who finished perfectly in a one-on-one to open the scoring past the half-hour mark. Just a few minutes later, Amaiur Sarriegi capped off a great counter-attack by the Atlético players to double their lead on the scoreboard. Just before half-time, Fiamma scored the third with a shot from outside the box, but the referee disallowed it for an earlier foul. In the second half, José Herrera's side managed to score the third through Fiamma, who cut inside the box and beat Olatz Santana. In the final stages, Amaiur Sarriegi completed her brace. Meanwhile, Ane Azkona pulled one back to make it 4-1. 

Costa Adeje Tenerife will be the second Copa de la Reina semi-finalist. The Tenerife side took just two minutes to get ahead on the scoreboard. A cross from the wing led to an error by Paola Ulloa, and Sakina Ouzraoui capitalised on the goalkeeper's indecision to send the ball into the back of the net. Ángela Sosa looked for the equaliser, but without success. Again, Sakina Ouzraoui tried her luck in the home box, but this time, Paola Ulloa cleared the danger. In the second half, Madrid CFF tried, but it was Sandra Castelló who posed a threat with a shot that went into the side netting. Anita Marcos also tried her luck, but Nay Cáceres saved the striker's shot. The home side, who tried from set-pieces, pushed hard for an equaliser on the scoreboard. They even appealed for a possible penalty that the referee did not award. Emilie Nautnes had the last chance with a header that went wide.